Cost-effectiveness of statin therapy for secondary prevention among patients with coronary artery disease and baseline LDL-C 70–100 mg/dL in Taiwan
| Autor: | Wayne Huey-Herng Sheu, Kou-Gi Shyu, I-Chang Hsieh, Shoou-Jeng Yeh, Hung-I Yeh, Shih-Te Tu, Chin-I Chen, Wen-Yi Shau, Timothy J. Inocencio, Fang-Ju Lin, Chia-Chao Wu, Yao-Chun Wen, Kuo-Cheng Lu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Statin Cost effectiveness medicine.drug_class Cost-Benefit Analysis Taiwan Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Low-density lipoprotein cholesterol Stroke health care economics and organizations lcsh:R5-920 business.industry Mortality rate Incidence (epidemiology) Secondary prevention Cost-effectiveness analysis General Medicine Cholesterol LDL medicine.disease 030220 oncology & carcinogenesis Cohort 030211 gastroenterology & hepatology Quality-Adjusted Life Years Hydroxymethylglutaryl-CoA Reductase Inhibitors business lcsh:Medicine (General) |
| Zdroj: | Journal of the Formosan Medical Association, Vol 119, Iss 5, Pp 907-916 (2020) |
| ISSN: | 0929-6646 |
| Popis: | Background: The recommended target low-density lipoprotein cholesterol (LDL-C) level for coronary artery disease (CAD) patients has been lowered from 100 to 70 mg/dL in several clinical guidelines for secondary prevention. We aimed to assess whether initiating statin treatment in CAD patients with baseline LDL-C 70–100 mg/dL in Taiwan could be cost-effective. Methods: A Markov model was developed to simulate a hypothetical cohort of CAD patients with a baseline LDL-C level of 90 mg/dL. The incidence and recurrence of MI and stroke related to specific LDL-C levels as well as the statin effect, mortality rate, and health state utilities were obtained from the literature. The direct medical costs and rate of fatal events were derived from the national claims database. The incremental cost-effectiveness ratio (ICER) per quality-adjusted life years (QALYs) was calculated, and sensitivity analyses were performed. Results: Moderate-intensity statin use, a treatment regimen expected to achieve LDL |
| Databáze: | OpenAIRE |
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