Identification of differentially expressed genes-related prognostic risk model for survival prediction in breast carcinoma patients
| Autor: | Jinyu Li, Caixia Ren, Ning Wang, Gena Huang, Man Li, Zuowei Zhao, Silei Sui |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
differentially expressed genes Aging medicine.medical_specialty prognostic risk model Breast Neoplasms Models Biological breast cancer Breast cancer Risk Factors Internal medicine Databases Genetic Gene expression medicine Humans Protein Interaction Maps RNA Messenger Stage (cooking) prognostic outcome Gene Proportional Hazards Models Framingham Risk Score Proportional hazards model business.industry Gene Expression Profiling Cell Biology Cell cycle Prognosis medicine.disease Survival Analysis Gene Expression Regulation Neoplastic Gene Ontology Multivariate Analysis Female business Breast carcinoma Research Paper Cox regression |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.203178 |
| Popis: | Since the imbalance of gene expression has been demonstrated to tightly related to breast cancer (BRCA) genesis and growth, common genes expressed of BRCA were screened to explore the essence in-between. In current work, most common differentially expressed genes (DEGs) in various subtypes of BRCA were identified. Functional enrichment analysis illustrated the driving factor of deactivation of the cell cycle and the oocyte meiosis, which critically triggers the development of BRCA. Herein, we constructed a 12-gene prognostic risk model relative to differential gene expression. Subsequently, the K-M curves, analysis on time-ROC curve and Cox regression were performed to assess this risk model by determining the respective prognostic value, and the prediction performance were ascertained for both training and validation cohorts. In addition, multivariate Cox regression was analysed to reveal the independence between risk score and prognostic stage, and the accuracy and sensitivity of prognosis are particularly improved after clinical indicators are included into the analysis. In summary, this study offers novel insights into the imbalance of gene expression within BRCA, and highlights 12 selected genes associated with patient prognosis. The risk model can help individualize treatment for patients at different risks, and propose precise strategies and treatments for BRCA therapy. |
| Databáze: | OpenAIRE |
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