| Autor: |
Yiliang Lin, Bozhi Tian, Xiaolei Cai, Nicholas Ankenbruck, Pablo Penaloza-MacMaster, Aleksander Prominski, Jun Huang, Jiuyun Shi, Jillian Rosenberg, Eugene B. Chang, Min Chen |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
bioRxiv |
| Popis: |
The outbreak of 2019 coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic. Despite intensive research including several clinical trials, currently there are no completely safe or effective therapeutics to cure the disease. Here we report a strategy incorporating neutralizing antibodies conjugated on the surface of a photothermal nanoparticle to actively capture and inactivate SARS-CoV-2. The photothermal nanoparticle is comprised of a semiconducting polymer core and a biocompatible polyethylene glycol surface decorated with neutralizing antibodies. Such nanoparticles displayed efficient capture of SARS-CoV-2 pseudoviruses, excellent photothermal effect, and complete inhibition of viral entry into ACE2-expressing host cells via simultaneous blocking and inactivating of the virus. This photothermal nanoparticle is a flexible platform that can be readily adapted to other SARS-CoV-2 antibodies and extended to novel therapeutic proteins, thus providing a broad range of protection against multiple strains of SARS-CoV-2. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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