Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy
| Autor: | Piero Picci, Michela Versari, Gaetano Bacci, Antonio Briccoli, Franca Fagioli, Alessandra Longhi |
|---|---|
| Přispěvatelé: | Bacci G, Longhi A, Fagioli F, Briccoli A, Versari M, Picci P. |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Limb salvage Histological response Antineoplastic Agents Bone Neoplasms Disease-Free Survival Postoperative Complications Neoplasms medicine Chemotherapy Humans Child Preschool Adjuvant Aged Retrospective Studies Osteosarcoma business.industry Follow-up Infant Newborn Infant Neoplasms Second Primary Extremities Retrospective cohort study Middle Aged Newborn medicine.disease Surgery Chemotherapy Adjuvant Child Preschool Female Neoplasm Recurrence Local Treatment Outcome Oncology Neoplasm Recurrence Second Primary Local Second Malignancy Sarcoma business |
| Zdroj: | European Journal of Cancer. 41:2836-2845 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2005.08.026 |
| Popis: | Around 1148 patients with non-metastatic osteosarcoma of the extremity were treated in a single institution between 1972 and 1999 with 4 different protocol of adjuvant and 7 different protocols of neoadjuvant chemotherapy. The rate of limb salvage increased from 20% to 71%. The 5-year event-free survival (EFS) and overall survival (OS) were 57% and 66%, respectively. The 10-year EFS and OS were 52% and 57%, respectively, and the results significantly correlated with serum alkaline phosphatase levels; the type of chemotherapy (adjuvant vs neoadjuvant); and with histologic response to pre-operative treatment. Aggressive chemotherapy and surgery could cure about the 60% of patients with osteosarcoma of the extremity. However, since local or systemic relapses, myocardiopathies and a second malignancy are possible even 5 or more years since the beginning of treatment, a long-term follow-up is recommended. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect