Kala-azar in a high transmission focus: an ethnic and geographic dimension
| Autor: | N. S. Deifalla, Douglas C. Barker, Eltahir A G Khalil, A.M. El Hassan, Azzam Ismail, A. Y. Kadaro, D. A. Alnaiem, H. Yousif, B. Lambson, M.E. Ibrahim, A. O. Yousif, H. W. Ghalib |
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| Rok vydání: | 1999 |
| Předmět: |
Leishmania donovani
Black People Polymerase Chain Reaction Asymptomatic law.invention Sudan law Virology parasitic diseases Ethnicity Prevalence medicine Animals Humans Genetic Predisposition to Disease Prospective Studies Polymerase chain reaction DNA Primers Retrospective Studies Skin Tests Subclinical infection biology Transmission (medicine) Leishmaniasis DNA Protozoan Leishmania biology.organism_classification medicine.disease Occupational Diseases Cross-Sectional Studies Infectious Diseases Visceral leishmaniasis Immunology Leishmaniasis Visceral Parasitology medicine.symptom geographic locations Follow-Up Studies |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 61:941-944 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | In 1994-1996, we studied a group of 58 game wardens stationed in an area known to be highly endemic for visceral leishmaniasis (kala-azar) for evidence of infection with Leishmania donovani. Leishmania DNA was detected by the polymerase chain reaction in the peripheral blood of cases of active kala-azar, former patients with visceral leishmaniasis, patients, and asymptomatic subjects. Using the cloned antigen rk39, antibodies were detected in 44.2% of the game wardens while leishmanin skin test result was positive in 77% of our sample. It was shown that certain tribes from northern Sudan were more likely to develop subclinical infections, while those of the Baria tribe from southern Sudan and those of the Nuba tribe from western Sudan were more likely to develop visceral leishmaniasis. Whether this is due to genetic factors or previous exposure to Leishmania parasites remains to be elucidated. |
| Databáze: | OpenAIRE |
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