Further sesquiterpenoids from Pittosporum qinlingense and their anti-inflammatory activity

Autor: Ji-Li Deng, Rong Huang, Qiang-Guo Zhang, Bai-Tong Sha, Min-Chang Wang, Shang-Yong Deng, Jin-Ming Gao, Xiu-Yun Zhang
Rok vydání: 2022
Předmět:
Zdroj: Fitoterapia. 162
ISSN: 1873-6971
Popis: Four new sesquiterpenoid glycoside esters, Pitqinlingoside N-Q (1-4), together with eleven known metabolites (5-15), were isolated from 95% EtOH extract of the twigs, fruits and leaves of P. qinlingense. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including IR, UV, HRMS, NMR and electronic circular dichroism spectra. Unusal glycoside esters are characterized by the presence of polyacylated β-D-fucopyranosyl and β-d-glucopyranosyl units. Pitqinlingoside N (1), O (2), P (3), boscialin (5) and arvoside C (6) showed significant nitric oxide production inhibition in lipopolysaccharide (LPS)-induced BV-2 microglial cells with IC
Databáze: OpenAIRE