Voltammetric behavior of cefixime and cefpodoxime proxetil and determination in pharmaceutical formulations and urine
| Autor: | T. Madhusudana Reddy, Mallipattu Sreedhar, S. Jayarama Reddy |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Detection limit
Cefpodoxime Proxetil Chromatography Chemistry Chemistry Pharmaceutical Clinical Biochemistry Ceftizoxime Pharmaceutical Science Cefpodoxime Dosage form Analytical Chemistry Pharmaceutical Preparations Cefixime Drug Discovery medicine Electrochemistry Differential pulse voltammetry Voltammetry Quantitative analysis (chemistry) Spectroscopy medicine.drug |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 31(4) |
| ISSN: | 0731-7085 |
| Popis: | Electrochemical reduction behavior of cephalosporins, Cefixime (CF) and Cefpodoxime Proxetil (CP) have been studied by using different voltammetric techniques in Britton-Robinson buffer system. Two well defined cathodic waves are observed for both the compounds in the entire pH range. Number of electrons transferred in the reduction process was calculated and the reduction mechanism is proposed. The results indicate that the process of both the compounds is irreversible and diffusion-controlled. The peak currents for CF and CP are found to be linear over the range of concentration 6.0 x 10(-8) to 1.2 x 10(-5) mol l(-1) and 8.8 x 10(-8) to 1.1 x 10(-5) mol l(-1), respectively. The lower detection limits are found to be 4.6 x 10(-8) and 8.52 x 10(-8) mol l(-1) for the two compounds. A differential pulse voltammetric method has been developed for the determination of these drugs in pharmaceutical formulations and urine samples. |
| Databáze: | OpenAIRE |
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