Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma
| Autor: | J G Camblin, K Y Tsang, B. T. Shannon, J P Pandey, H H Fudenberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1982 |
| Předmět: |
Heterozygote
Osteosarcoma Immunology Chromosome Mapping Heterozygote advantage Articles Biology medicine.disease Phenotype Immunoglobulin G Loss of heterozygosity Antigen Antigens Neoplasm Humoral immunity Antibody Formation biology.protein medicine Immunology and Allergy Humans Antibody Immunoglobulin Allotypes |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Serum samples from 50 Caucasian patients with osteosarcoma were tested for the presence of antibodies to osteosarcoma-associated antigens (OSAA) and typed for nine Gm markers. A highly significant association was found between Gm 3;5,13,14 and unresponsiveness to OSAA, and between 1,3,17;5,13,14,21 and responsiveness to OSAA. These results suggest the existence of complementary immune response genes which in the heterozygous condition permit a response to OSAA. |
| Databáze: | OpenAIRE |
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