Neuropharmacological effects of the ethanolic extract of Sida acuta
| Autor: | Dora Benjumea, Fernando Alzate, Julieta Vásquez, José Angel Fontenla, Andrea García-Silva, Isabel Gómez-Betancur |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pentobarbital
Anxiolytic activity Astringent medicine.drug_class Rota rod lcsh:RS1-441 Pharmacology Anxiolytic Hypnotic lcsh:Pharmacy and materia medica Pharmacology Toxicology and Pharmaceutics(all) 03 medical and health sciences 0302 clinical medicine medicine General Pharmacology Toxicology and Pharmaceutics Malvaceae biology Sida acuta business.industry Anticonvulsant activity biology.organism_classification Blood Disorder Sodium pentobarbital-induced sleeping time 030220 oncology & carcinogenesis Sedative business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 26, Iss 2, Pp 209-215 Revista Brasileira de Farmacognosia v.26 n.2 2016 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Volume: 26, Issue: 2, Pages: 209-215, Published: APR 2016 Revista Brasileira de Farmacognosia, Vol 26, Iss 2, Pp 209-215 (2016) |
| Popis: | Sida acuta Burm. f., Malvaceae, is regarded as astringent, tonic and useful in treating urinary diseases and blood disorders, bile, liver and as treatment for nervous diseases. Different methods were developed: sodium pentobarbital-induced sleeping time, anxiolytic activity, test for muscle-effects, pentylenetetrazole (PTZ)-induced seizures, effect on normal body temperature. All experiments were performed in an isolated room with 12/12 h light/dark cycles at 22 ± 1 °C. The effects described in this work for Sida acuta are according to what is known in traditional medicine, where is used as sedative agent. At the higher doses used in this work (500 and 1000 mg/kg), the Sida acuta extract reduced the latency time (T1) and increased the sleeping time (T2) induced by pentobarbital, indicating a sedative and hypnotic effect of the plant's extract. The extract of Sida acuta shows an increase in open arm exploration (anxiolytic activity). Results obtained in the rota-rod test showed that only the elevated dose (750 mg/kg) of Sida acuta extract, acutely administered, promotes significant changes, at 60 and 120 min post-administration, in the time of permanence in the rod. The ethanolic extract from the leaves and stems of Sida acuta, causes effects on the central nervous system in experimental animals. Keywords: Anxiolytic activity, Anticonvulsant activity, Rota rod, Sodium pentobarbital-induced sleeping time |
| Databáze: | OpenAIRE |
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