A Midzone-Based Ruler Adjusts Chromosome Compaction to Anaphase Spindle Length
| Autor: | Iris Titos, Toni Gabaldón, Dominik Theler, Basil J. Greber, Gabriel Neurohr, Andreas Naegeli, Javier Díez, Manuel Mendoza, Yves Barral |
|---|---|
| Přispěvatelé: | Universidad de Navarra [Pamplona] (UNAV), Center for Genomic Regulation (CRG-UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institute of Biochemistry, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Saccharomyces cerevisiae Proteins
[SDV]Life Sciences [q-bio] Saccharomyces cerevisiae Spindle Apparatus Protein Serine-Threonine Kinases Biology Spindle pole body Spindle elongation Histones 03 medical and health sciences 0302 clinical medicine Aurora Kinases Chromosome Segregation Centromere Aldose-Ketose Isomerases ComputingMilieux_MISCELLANEOUS 030304 developmental biology Anaphase Genetics 0303 health sciences Multidisciplinary Kinetochore Spindle midzone Intracellular Signaling Peptides and Proteins Spindle apparatus Cell biology Spindle checkpoint Mutation Chromosomes Fungal Microtubule-Associated Proteins 030217 neurology & neurosurgery |
| Zdroj: | Science Science, American Association for the Advancement of Science, 2011, 332 (6028), pp.465-468. ⟨10.1126/science.1201578⟩ |
| ISSN: | 0036-8075 1095-9203 |
| DOI: | 10.1126/science.1201578⟩ |
| Popis: | Partitioning of chromatids during mitosis requires that chromosome compaction and spindle length scale appropriately with each other. However, it is not clear whether chromosome condensation and spindle elongation are linked. Here, we find that yeast cells could cope with a 45% increase in the length of their longest chromosome arm by increasing its condensation. The spindle midzone, aurora/Ipl1 activity, and Ser10 of histone H3 mediated this response. Thus, the anaphase spindle may function as a ruler to adapt the condensation of chromatids, promoting their segregation regardless of chromosome or spindle length. |
| Databáze: | OpenAIRE |
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