Recombinant Thyrotropin in the Diagnosis of Congenital Hypothyroidism
Autor: | Dov Tiosano, Lea Even, Zeev Hochberg, Zila Shen Orr |
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Rok vydání: | 2007 |
Předmět: |
Male
endocrine system medicine.medical_specialty Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyroid Gland Thyrotropin Context (language use) Biochemistry Thyrotropin receptor Endocrinology Hypothyroidism Thyroid-stimulating hormone Internal medicine Area under curve medicine Humans Radionuclide imaging Child business.industry Biochemistry (medical) Thyroid medicine.disease Recombinant Proteins Congenital hypothyroidism medicine.anatomical_structure Child Preschool Female business |
Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 92:1434-1437 |
ISSN: | 1945-7197 0021-972X |
DOI: | 10.1210/jc.2006-2134 |
Popis: | Context: A modern approach to congenital hypothyroidism requires a definitive diagnosis of the underlying mechanisms; this can be achieved within the first weeks of life. When uncertainty persists, treatment is commenced, and the definitive diagnosis of congenital hypothyroidism is deferred to the age of 3 yr. Objectives: The interruption of thyroid replacement treatment is perceived as risky by parents and physicians. The aim of this pilot study was to test the possibility of a definitive diagnosis during thyroid replacement treatment, using stimulation of thyroid tissue by recombinant human (rh)TSH. Subjects: Eight patients, three boys and five girls, age 5–15 yr (mean, 9.5 ± 3.7 yr), with congenital hypothyroidism that had been diagnosed by the neonatal screening program, and having their diagnosis verified between the ages of 3–4 yr, were reevaluated while on thyroid replacement therapy. Interventions: Patients received im 0.6 mg/m2 rhTSH on two consecutive days. Results: rhTSH pharmacokinetics, maximal concentration, t1/2, and area under the curve in children were different as compared with adults. In the patients with intact TSH receptors, free T4 levels decreased after the first and the second injection of rhTSH (P = 0.0137 and P = 0.0149, respectively). All eight children showed identical scintigraphy after rhTSH administration as compared with thyroid replacement withdrawal. Conclusions: The use of rhTSH is effective for definitive diagnosis of congenital hypothyroidism during thyroid replacement treatment, and no safety issues were encountered. |
Databáze: | OpenAIRE |
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