Pharmacological targets revealed by myocardial postconditioning
| Autor: | Gary F. Baxter, Dwaine Simon Burley |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Programmed cell death
Cardiotonic Agents Narcotic Antagonists Ischemia Myocardial Ischemia Myocardial Reperfusion Injury Pharmacology Mitochondrial Membrane Transport Proteins Reperfusion therapy Drug Delivery Systems Drug Discovery Purinergic P1 Receptor Agonists Medicine Animals Humans Myocardial infarction business.industry Mitochondrial Permeability Transition Pore Receptors Purinergic P1 medicine.disease Mitochondrial permeability transition pore Purinergic P1 Receptor Antagonists Anesthesia Ischemic Preconditioning Myocardial Receptors Opioid Ischemic preconditioning business Autacoid Apoptosis Regulatory Proteins Reperfusion injury Atrial Natriuretic Factor Autacoids |
| Zdroj: | Current opinion in pharmacology. 9(2) |
| ISSN: | 1471-4892 |
| Popis: | Postconditioning is an intervention in which controlled, brief, intermittent periods of ischaemia at the onset of reperfusion protect myocardium from the lethal consequences of reperfusion ('reperfusion injury'). Postconditioning has been demonstrated in humans with acute myocardial infarction and offers the possibility of further limiting infarct size in patients undergoing reperfusion therapy. We review current research that focuses on the molecular mechanisms of postconditioning. The molecular pathways are incompletely mapped but they probably converge on suppression of mitochondrial permeability transition pore opening during early reperfusion, an event that is thought to promote cell death at reperfusion. A number of upstream signalling pathways, activated by autacoid factors, converge on this crucial target and these offer a range of realistic possibilities for pharmacological induction of a postconditioned state. |
| Databáze: | OpenAIRE |
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