Impacts of RETN genetic polymorphism on breast cancer development
| Autor: | Lulu Jin, Jin Zhao, Huey En Tzeng, Chih-Hsin Tang, Xiaoni Li, Hongchuan Jin, Chen Ming Su, Chao Qun Wang, Yong Ming Zhao, Yan Wang, Bi Fei Huang, Le Kang, Gui Nv Hu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Adipokine The Cancer Genome Atlas Single-nucleotide polymorphism Disease 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer single nucleotide polymorphism Internal medicine Genotype medicine SNP resistin business.industry Odds ratio medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Resistin business Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | The adipokine resistin is linked with obesity, inflammation and various cancers, including breast cancer. This study sought to determine whether certain polymorphisms in the gene encoding resistin, RETN, increase the risk of breast cancer susceptibility. We analyzed levels of resistin expression in breast cancer tissue and samples from The Cancer Genome Atlas database. We also examined associations between four RETN single nucleotide polymorphisms (SNPs; rs3745367, rs7408174, rs1862513 and rs3219175) and breast cancer susceptibility in 515 patients with breast cancer and 541 healthy women without cancer. Compared with wild-type (GG) carriers, those carrying the AG genotype of the RETN SNP rs3219175 and those carrying at least one A allele in the SNP rs3219175 had a higher chance of developing breast cancer (adjusted odds ratio, AOR: 1.295, 95% confidence intervals, CI: 1.065-1.575 and 2.202, 1.701-2.243, respectively). When clinical aspects and the RETN SNP rs7408174 were examined in the breast cancer cohort, the CT genotype was linked to late-stage disease, while women with luminal A disease and at least one C allele were likely to progress to stage III/IV disease and to develop highly pathological grade III disease. Moreover, resistin-positive individuals were at greater risk than resistin-negative individuals for developing pathological grade III disease (OR: 5.020; 95% CI: 1.380-18.259). This study details risk associations between resistin and RETN SNPs in breast cancer susceptibility in Chinese Han women. |
| Databáze: | OpenAIRE |
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