Evidence Suggesting Persistence of Nephritogenic Immunopathologic Mechanisms in Patients Receiving Renal Allografts
| Autor: | R. B. Smith, R. DeLemos, A. B. Cosimi, Alfred L. Thompson, Robert E. Lordon, G. Klebanoff, John J. McPhaul |
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| Rok vydání: | 1973 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Kidney Glomerulus Fluorescent Antibody Technique Immunoglobulins Basement Membrane Persistence (computer science) Glomerulonephritis Transplantation Immunology Histocompatibility Antigens medicine Animals Humans Transplantation Homologous Child Kidney transplantation Basement membrane biology urogenital system Immune Sera Articles General Medicine Middle Aged medicine.disease Kidney Transplantation Histocompatibility Transplantation surgical procedures operative medicine.anatomical_structure Child Preschool Immunology Immunologic Techniques biology.protein Female Rabbits Antibody |
| Zdroj: | Journal of Clinical Investigation. 52:1059-1066 |
| ISSN: | 0021-9738 |
| Popis: | Direct immunofluorescent (IF) examinations and elutions were performed on native kidneys and allografts of 24 patients undergoing renal transplantation. Immunoglobulins (Ig) were detected by IF on native kidneys of 12 of the 24; 11 of the 12 later had Ig localized to allograft glomeruli by direct IF. In addition, three other patients also developed Ig deposition on allograft glomeruli, although direct IF of native kidneys was negative. Elution studies indicated: (a) that linear Ig deposition on allograft glomeruli was the result of antiglomerular basement membrane (GBM) antibodies, (b) Ig localizing to allograft glomeruli in many of these patients was the result of persistent immunopathogenetic mechanisms existing at the time of allograft placement, and (c) occasionally, kidneys negative for Ig localization by direct IF contain elutable nephritogenic antibodies. |
| Databáze: | OpenAIRE |
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