Achlorhydria-induced hypergastrinaemia: the role of bacteria
Autor: | Nicholas A. Wright, J. Calam, B. Ratcliffe, Chung Y. Lee, M. E. Coates, G W H Stamp, Robert A. Goodlad |
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Rok vydání: | 1991 |
Předmět: |
medicine.medical_specialty
Biology Achlorhydria Gastric Acid Leukocyte Count Histamine H2 receptor Internal medicine Gastrins medicine Gastric mucosa Animals Germ-Free Life Secretion Gastrin Dose-Response Relationship Drug Helicobacter pylori Stomach digestive oral and skin physiology Antagonist Rats Inbred Strains General Medicine Triazoles medicine.disease Rats Eosinophils Endocrinology medicine.anatomical_structure Histamine H2 Antagonists Gastric Mucosa Gastric acid |
Zdroj: | Clinical science (London, England : 1979). 80(4) |
ISSN: | 0143-5221 |
Popis: | 1. Studies of Helicobacter pylori show that microbes can alter gastrin release. Lack of gastric acid (achlorhydria) causes hypergastrinaemia and allows bacteria to grow within the stomach. We speculated that the bacteria contribute to the rise in gastrin seen after acid inhibition, and tested the idea by comparing plasma gastrin levels during inhibition of acid secretion between germ-free and conventional rats. 2. Matched germ-free and conventional rats (n = 8 per group) received either vehicle (saline) or one of two doses of the histamine-H2-receptor antagonist loxtidine for 1 week. Gastrin was measured in cardiac blood by a specific r.i.a. 3. Plasma gastrin concentrations in germ-free and conventional rats were 59 ± 11 pmol/l (mean ± SEM) and 36 ± 8 pmol/l, respectively, after vehicle, and 153 ± 30 pmol/l and 181 ± 27 pmol/l, respectively, after loxtidine at a dose of 10 mg day−1 kg−1, which partially inhibits acid secretion. Administration of loxtidine at a dose of 70 mg day−1 kg−1, which completely inhibits acid secretion, did not produce a significant extra rise in plasma gastrin concentration in germ-free rats (178 ± 11 pmol/l), but further elevated plasma gastrin concentrations to 278 ± 26 pmol/l in conventional rats (P 4. Loxtidine produced a dose-dependent rise in the number of eosinophils in the gastric mucosa of conventional rats. 5. We conclude that partial inhibition of gastric acid secretion increases gastrin release independently of bacteria, but that bacteria are involved in the further rise in gastrin which occurs on more profound inhibition of gastric acid secretion. |
Databáze: | OpenAIRE |
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