Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease mice
| Autor: | Mushtaq A. Memon, Thamilarasan Manivasagam, Musthafa Mohammed Essa, Jagatheesan Nataraj, M. Kavitha |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Parkinson's disease Dopamine Xanthones Apoptosis Pharmacology Motor Activity Toxicology medicine.disease_cause Neuroprotection chemistry.chemical_compound Mice medicine Animals Mangiferin bcl-2-Associated X Protein MPTP Dopaminergic Neurons Neurodegeneration Dopaminergic MPTP Poisoning General Medicine medicine.disease Mice Inbred C57BL Disease Models Animal Oxidative Stress Neuroprotective Agents chemistry Biochemistry Proto-Oncogene Proteins c-bcl-2 Lipid Peroxidation Oxidation-Reduction Oxidative stress medicine.drug |
| Zdroj: | Chemico-biological interactions. 206(2) |
| ISSN: | 1872-7786 |
| Popis: | Mangiferin, a polyphenol compound of C-glucoside, is well-known for its anti-inflammatory, antioxidant, anticancer, antidiabetic and cognitive enhancement properties. In this study, we investigated the neuroprotective effect of mangiferin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD), which is most popular and widely used to evaluate therapeutic implications of new protective agents. Male C57BL/6 mice were orally treated with mangiferin (10, 20 and 40 mg/kg body wt.) for 14 days and from 10th day onwards MPTP (30 mg/kg, i.p.) was injected for last 5 days. MPTP treatment leads to enhanced oxidative stress, induction of apoptosis (upregulates the expression of Bax, proapoptotic protein and downregulates the expression of anti-apoptotic marker Bcl-2), and loss of dopominergic neurons which results in motor impairments. Results of our study confirmed that mangiferin prevented MPTP-induced behavioral deficits, oxidative stress, apoptosis, dopaminergic neuronal degeneration and dopamine depletion. Taken together, we conclude that mangiferin attenuates the dopaminergic neurodegeneration mainly through its potent antioxidant and antiapoptotic properties. |
| Databáze: | OpenAIRE |
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