Noradrenergic neuronal dysregulation in panic disorder: the effects of intravenous yohimbine and clonidine in panic disorder patients
| Autor: | Dennis S. Charney, L. M. Nagy, Scott W. Woods, George R. Heninger, John H. Krystal |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Personality Inventory Blood Pressure behavioral disciplines and activities Clonidine Methoxyhydroxyphenylglycol Norepinephrine Double-Blind Method Internal medicine mental disorders medicine Humans Infusions Intravenous business.industry Panic disorder Panic Yohimbine medicine.disease Pathophysiology Receptors Adrenergic Psychiatry and Mental health Endocrinology Anesthesia Growth Hormone Anxiety Panic Disorder Female medicine.symptom business Arousal Anxiety disorder medicine.drug |
| Zdroj: | Acta psychiatrica Scandinavica. 86(4) |
| ISSN: | 0001-690X |
| Popis: | In order to evaluate possible abnormal noradrenergic neuronal functional regulation in patients with panic disorder, the behavioral, biochemical and cardiovascular effects of intravenous yohimbine (0.4 mg/kg) and clonidine (2 micrograms/kg) were determined in 15 healthy subjects and 38 patients with panic disorder. A subgroup of 24 panic disorder patients were observed to experience yohimbine-induced panic attacks and had larger yohimbine-induced increases in plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) than healthy subjects and other panic disorder patients. A blunted growth hormone response to clonidine and a significant clonidine-induced decrease in plasma MHPG was also observed in this subgroup of panic disorder patients. These data replicate and extend previous investigations, which are consistent with a large body of preclinical and human data relating increased noradrenergic neuronal function to human anxiety and fear states. |
| Databáze: | OpenAIRE |
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