The Sickness Behavior Inventory-Revised: Sickness behavior and its associations with depression and inflammation in patients with metastatic lung cancer
| Autor: | Leah E. Walsh, Christian J. Nelson, Daniel C. McFarland, Rebecca M. Saracino, Barry Rosenfeld, William Breitbart |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Lung Neoplasms Multivariate analysis Psychometrics Hospital Anxiety and Depression Scale Article 03 medical and health sciences 0302 clinical medicine Cronbach's alpha Surveys and Questionnaires Internal medicine Humans Medicine Lung cancer General Nursing Sickness behavior Depression (differential diagnoses) Illness Behavior Inflammation biology Depression business.industry C-reactive protein Reproducibility of Results Construct validity General Medicine medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical Psychology biology.protein business 030217 neurology & neurosurgery |
| Zdroj: | Palliat Support Care |
| ISSN: | 1478-9523 1478-9515 |
| DOI: | 10.1017/s1478951520001169 |
| Popis: | BackgroundInflammation may contribute to the high prevalence of depressive symptoms seen in lung cancer. “Sickness behavior” is a cluster of symptoms induced by inflammation that are similar but distinct from depressive symptoms. The Sickness Behavior Inventory-Revised (SBI-R) was developed to measure sickness behavior. We hypothesized that the SBI-R would demonstrate adequate psychometric properties in association with inflammation.MethodParticipants with stage IV lung cancer (n = 92) were evaluated for sickness behavior using the SBI-R. Concomitant assessments were made of depression (Patient Hospital Questionniare-9, Hospital Anxiety and Depression Scale) and inflammation [C-reactive protein (CRP)]. Classical test theory (CTT) was applied and multivariate models were created to explain SBI-R associations with depression and inflammation. Factor Analysis was also used to identify the underlying factor structure of the hypothesized construct of sickness behavior. A longitudinal analysis was conducted for a subset of participants.ResultsThe sample mean for the 12-item SBI-R was 8.3 (6.7) with a range from 0 to 33. The SBI-R demonstrated adequate internal consistency with a Cronbach's coefficient of 0.85, which did not increase by more than 0.01 with any single-item removal. This analysis examined factor loadings onto a single factor extracted using the principle components method. Eleven items had factor loadings that exceeded 0.40. SBI-R total scores were significantly correlated with depressive symptoms (r = 0.78, p < 0.001) and CRP (r = 0.47, p < 0.001). Multivariate analyses revealed that inflammation and depressive symptoms explained 67% of SBI-R variance.Significance of resultsThe SBI-R demonstrated adequate reliability and construct validity in this patient population with metastatic lung cancer. The observed findings suggest that the SBI-R can meaningfully capture the presence of sickness behavior and may facilitate a greater understanding of inflammatory depression. |
| Databáze: | OpenAIRE |
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