Antidepressant drug treatment induces Arc gene expression in the rat brain
| Autor: | Tyra S.C. Zetterström, M Sprakes, R Tordera, Trevor Sharp, Q Pei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Monoamine Oxidase Inhibitors Chlorpromazine medicine.drug_class UoA 13 Pharmacy Gene Expression Nerve Tissue Proteins Pharmacology Biology Synaptic Transmission Rats Sprague-Dawley chemistry.chemical_compound Prosencephalon Internal medicine Desipramine medicine Animals RNA Messenger Neurotransmitter Monoamine oxidase inhibitor Neuronal Plasticity Arc (protein) General Neuroscience RAE 2008 Tranylcypromine Venlafaxine Hydrochloride Brain Cyclohexanols Antidepressive Agents Rats Up-Regulation Cytoskeletal Proteins Paroxetine Monoamine neurotransmitter Endocrinology chemistry Antidepressant Reuptake inhibitor Selective Serotonin Reuptake Inhibitors medicine.drug |
| DOI: | 10.1016/s0306-4522(03)00504-9 |
| Popis: | The mechanism underlying the therapeutic effect of antidepressants is not known but neuroadaptive processes akin to long-term potentiation have been postulated. Arc (Activity-regulated, cytoskeletal-associated protein) is an effector immediate early gene implicated in LTP and other forms of neuroplasticity. Recent data show that Arc expression is regulated by brain 5-hydroxytryptamine neurones, a target of many antidepressants. Here in situ hybridisation and immunohistochemistry were used to examine whether Arc expression in rat brain is altered by antidepressant drug treatment. Repeated administration of the monoamine reuptake inhibitors paroxetine, venlafaxine or desipramine induced region-specific increases in Arc mRNA. These increases were greatest in regions of the cortex (frontal and parietal cortex) and hippocampus (CA1 layer) and absent in the caudate putamen. Repeated treatment with the monoamine oxidase inhibitor, tranylcypromine, increased Arc mRNA in a similar fashion to the monoamine reuptake inhibitors. The antidepressant drugs also increased the number of Arc-immunoreactive cells in the parietal cortex. Acute antidepressant injection, and repeated administration of the antipsychotic drug chlorpromazine, produced either limited or no changes in Arc mRNA. The data suggest that chronic treatment with antidepressant drugs induces Arc gene expression in specific regions across the rat forebrain. Up-regulation of Arc expression may be part of the process by which antidepressant drugs achieve long-term changes in synaptic function in the brain. |
| Databáze: | OpenAIRE |
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