The retinoic acid and retinoid X receptors are differentially expressed during myoblast differentiation
| Autor: | Meredith Downes, George E.O. Muscat, Lesley Mynett-Johnson |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Receptors Retinoic Acid Retinoic acid Gene Expression Receptors Cytoplasmic and Nuclear Retinoid X receptor Biology MyoD Cell Line Retinoic acid-inducible orphan G protein-coupled receptor Mice chemistry.chemical_compound Endocrinology Internal medicine medicine Animals RNA Messenger Retinoid X receptor alpha Muscles Cell Differentiation Blotting Northern musculoskeletal system Retinoid X receptor gamma body regions Retinoic acid receptor Retinoid X Receptors chemistry embryonic structures Retinoid X receptor beta tissues Transcription Factors |
| Zdroj: | Endocrinology. 134:2658-2661 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.134.6.8194491 |
| Popis: | Retinoids (all trans and 9-cis retinoic acid) are pleiotropic regulators of cell fate, and have been shown to regulate the expression of helix loop helix transcription factors (e.g MyoD, myogenin and Myf-5) that control myogenic differentiation. The effects of retinoids are mediated through the ligand dependent retinoic acid receptors (RARs) and retinoid X receptors (RXRs). We have found that the messenger RNA transcripts encoding RAR are repressed during differentiation of C2C12 myoblasts while, conversely, RXR mRNA transcripts are induced in C2C12 myotubes. These results imply that RXRs, play a major regulatory role in differentiated muscle. |
| Databáze: | OpenAIRE |
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