Influence of omega‐3 fatty acid on orthodontic tooth movement in rats: A biochemical, histological, immunohistochemical and gene expression study
| Autor: | Gozde Ogrenim, Tuna Onal, Murat Kara, Gizem Donmez Yalcin, Mine Geçgelen Cesur, Fevziye Burcu Sirin, Sevinc Inan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Tooth Movement Techniques Adult male Interleukin-1beta Gingiva Gene Expression Physiology Orthodontics Real-Time Polymerase Chain Reaction 03 medical and health sciences 0302 clinical medicine stomatognathic system Fatty Acids Omega-3 Gene expression Alveolar Process Animals Medicine 030212 general & internal medicine Rats Wistar Omega 3 fatty acid Interleukin-6 business.industry RANK Ligand 030206 dentistry Rats stomatognathic diseases Antioxidant capacity Otorhinolaryngology Tooth movement Systemic administration Immunohistochemistry Surgery Oral Surgery business |
| Zdroj: | Orthodontics & Craniofacial Research. 22:24-31 |
| ISSN: | 1601-6343 1601-6335 |
| DOI: | 10.1111/ocr.12253 |
| Popis: | OBJECTIVE The aim of this study was to investigate the effects of omega-3 fatty acids on orthodontic tooth movement. SETTING AND SAMPLE POPULATION For this study, 56 12-week-old adult male Wistar albino rats from the Animal Laboratory at Adnan Menderes University, Faculty of Medicine, were used. MATERIAL AND METHODS Rats were randomly divided into seven groups (n = 8 each): control group (without any treatment), tooth movement groups (three groups of animals with only tooth movement) and omega groups (three groups of animals with tooth movement and omega-3 administration). Omega-3 fatty acids were administered to the rats systemically during the tooth movement period. On the 3rd, 7th and 14th days after the orthodontic tooth movement, the rats were sacrificed and biochemical, histological, immunohistochemical andgene expression examinations were performed. RESULTS On the 14th experimental day, the amount of tooth movement in the omega groups was significantly lower than the tooth movement groups (P = 0.012). Biochemical experimentsshowed that the omega groups had significantly lower total oxidant levels and higher total antioxidant levels compared to the tooth movement group on the 14th experimental day (P = 0.001). The levels of RANKL, IL-6 and IL-1β in the omega groups were significantly lower than the tooth movement groups on all experimental days (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text