Valorisation of kitul, an overlooked food plant: Phenolic profiling of fruits and inflorescences and assessment of their effects on diabetes-related targets
| Autor: | Sutsawat Duangsrisai, Catarina Andrade, David M. Pereira, Paula B. Andrade, Patrícia Valentão, Angel Gil-Izquierdo, Federico Ferreres, Romeu A. Videira, Rungcharn Suksungworn, Nelson G.M. Gomes |
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| Přispěvatelé: | Fundação para a Ciência e a Tecnologia (Portugal), Ministério da Ciência, Tecnologia e Ensino Superior (Portugal), European Commission |
| Rok vydání: | 2019 |
| Předmět: |
Food plant
Caryota urens Functional foods Biology 01 natural sciences Analytical Chemistry chemistry.chemical_compound 0404 agricultural biotechnology Caffeic Acids Phenols Caffeic acid Humans Hypoglycemic Agents Glycoside Hydrolase Inhibitors Food science Caffeic acid derivatives Inflorescence Aldose reductase Plant Extracts α glucosidase 010401 analytical chemistry Diabetes food and beverages alpha-Glucosidases 04 agricultural and veterinary sciences General Medicine biology.organism_classification 040401 food science Yeast 0104 chemical sciences chemistry α-Glucosidase Fruit Valorisation Caco-2 Cells Plants Edible alpha-Amylases Food Science |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1873-7072 |
| Popis: | Caryota urens L. has long been valued as a traditional food, the edible fruits being eaten raw and the inflorescences commonly used on sweet sap and flour production. In the current work, the phenolic profile of methanol extracts obtained from the inflorescences and fruits was unveiled for the first time, nine caffeic acid derivatives being identified and quantified. Since kitul products have been reported for their antidiabetic properties, extracts radical scavenging activity and α-amylase, α-glucosidase and aldose reductase inhibitory activity were assessed. The inflorescences’ extract was particularly active against yeast α-glucosidase (IC = 1.53 μg/mL), acting through a non-competitive inhibitory mechanism. This activity was also observed in enzyme-enriched homogenates obtained from human Caco-2 cells (IC = 64.75 µg/mL). Additionally, the extract obtained from the inflorescences showed no cytotoxicity on HepG2, AGS and Caco-2 cell lines. Our data suggest that C. urens inflorescences can support the development of new functional foods with α-glucosidase inhibitory activity. Acknowledgements The work was supported by UIDB/50006/2020 with funding from Fig. 5. Effects of C. urens INF methanolic extract on (A) AGS, (B) HepG2 and (C) Caco-2 cell viability. (D) INF methanolextract inhibition of human α-glucosidase inhibition obtained from Caco-2 cells homogenates. Data represent the mean ± SD of at least three independent experiments, performed in triplicate. F. Ferreres, et al. Food Chemistry 342 (2021) 128323 8 FCT/MCTES through national funds, and by Programa de Cooperación Interreg V-A España – Portugal (POCTEP) 2014–2020 (project 0377_IBERPHENOL_6_E). N. Gomes is indebted to national funds through FCT - Fundação para a Ciência e a Tecnologia, I.P., under the project CEECIND/03037/2017. C. Andrade thanks FCT - Fundação para Ciência e a Tecnologia, I.P. for the grant SFRH/BD/131431/2017 |
| Databáze: | OpenAIRE |
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