Determinants of atherosclerosis in an Egyptian cohort of systemic sclerosis: Relation to disease activity and severity

Autor: Amr Zaher, Al-Hussein M. El-Dakrony, Khaled F. Alhassanein, Amina B. Eldin, Rehab Abdel Rahman, Samah A. Elbakry, Safaa Sayed, Ahmed Yousry
Rok vydání: 2016
Předmět:
Zdroj: The Egyptian Rheumatologist. 38(3):195-201
ISSN: 1110-1164
DOI: 10.1016/j.ejr.2015.11.003
Popis: BackgroundSystemic sclerosis (SSc) is a rare multi-system autoimmune disease characterized by vascular abnormalities with an increased prevalence of macrovascular disease.Aim of the workTo evaluate macro-vascular disease (atherosclerosis) in SSc patients and determine its relation to the disease activity and severity.Patients and methodsTwenty-five SSc patients and 20 matched controls were included. The modified Rodnan skin score (mRss) and disease severity by Medsger’s severity score were assessed. Carotid intima-media thickness (IMT) and flow mediated vasodilatation (FMD) of the brachial artery were measured. Traditional vascular risk factors were assessed by thorough history taking and laboratory investigations.ResultsThe age of the patients ranged from 15 to 60years and they were 22 females and 3 males. 15 had limited and 10 diffuse cutaneous SSc. All SSc patients had an increased IMT (1.24±0.29mm) which was normal in the control subjects (0.77±0.09mm) (p
Databáze: OpenAIRE
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