Combined Tumors in Hematolymphoid Neoplasms: Case Series of Histiocytic and Langerhans Cell Sarcomas Arising From Low-Grade B-Cell Lymphoma
| Autor: | William R. Macon, Jing C Ye, Frances R Quinones, Stephanie L. Skala, Rajan Dewar, Rhett P. Ketterling, Vadim Khachaturov, Jennifer Stumph |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Pathology medicine.medical_specialty Histology Langerhans cell Chronic lymphocytic leukemia Case Report Histiocytic sarcoma histiocytic sarcoma Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases lcsh:Pathology Medicine Low grade B-cell lymphoma Index case Histiocyte Transdifferentiation business.industry medicine.disease 030104 developmental biology medicine.anatomical_structure Langerhans cell sarcoma 030220 oncology & carcinogenesis chronic lymphocytic leukemia business lcsh:RB1-214 |
| Zdroj: | Clinical Pathology Clinical Pathology, Vol 12 (2019) |
| ISSN: | 2632-010X |
| Popis: | We report an index case of histiocytic sarcoma arising in a 70-year-old patient with long-standing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The patient presented in 2017 with painful, enlarging swelling of the left neck. He had remote history of cutaneous squamous cell carcinoma with no sign of recurrence, and his CLL/SLL was thought to be in remission. Computed tomography showed mild splenomegaly and multifocal lymphadenopathy including a 3-cm left neck mass. Biopsy of the left neck mass showed CLL/SLL with associated histiocytic sarcoma. Flow cytometry demonstrated a B cell neoplasm with CLL/SLL phenotype. Despite radiation therapy, he expired 3 months after presentation. Two similar cases (CLL/SLL and histiocytic sarcoma, follicular lymphoma and Langerhans cell sarcoma) from another institution are also illustrated. The pathological features of combined tumors in lymphoid neoplasms, a general framework to the work-up to determine interrelatedness of tumor components, and the clinical relevance are discussed. |
| Databáze: | OpenAIRE |
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