Self-Interactions of Two Monoclonal Antibodies: Small-Angle X-ray Scattering, Light Scattering, and Coarse-Grained Modeling
| Autor: | Sujata Mahapatra, Marco Polimeni, Lorenzo Gentiluomo, Dierk Roessner, Wolfgang Frieß, Günther H. J. Peters, Werner W. Streicher, Mikael Lund, Pernille Harris |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
X-Rays Antibodies Monoclonal Pharmaceutical Science 02 engineering and technology 021001 nanoscience & nanotechnology 03 medical and health sciences X-Ray Diffraction Scattering Small Angle Drug Discovery Molecular Medicine 0210 nano-technology Monte Carlo Method 030304 developmental biology |
| Zdroj: | Molecular Pharmaceutics |
| ISSN: | 1543-8392 1543-8384 |
| Popis: | Using light scattering (LS), small-angle X-ray scattering (SAXS), and coarse-grained Monte Carlo (MC) simulations, we studied the self-interactions of two monoclonal antibodies (mAbs), PPI03 and PPI13. With LS measurements, we obtained the osmotic second virial coefficient |
| Databáze: | OpenAIRE |
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