| Autor: |
Maria Nakou, Charalambos Giantselidis, Evangelia Theodoridou, Dimitrios Fotiou, Vasilios Stergiou, Irene Kalliolia, Dimitrios Tsiptsios, Catherine G. Brozou, Evangelia Giza |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Annals of General Psychiatry, Vol 5, Iss Suppl 1, p S322 (2006) |
| ISSN: |
1744-859X |
| DOI: |
10.1186/1744-859x-5-s1-s322 |
| Popis: |
Background Alzheimer's Disease (AD) is the leading cause of dementia, accounting for 70% of all dementias in old age. In clinical practice the diagnosis is based on typical features of the disease and exclusion of other conditions causing dementia or cognitive dysfunction. So far the diagnosis of definite AD can be confirmed only by brain biopsy or at autopsy. Therefore, a reliable noninvasive diagnostic method is mainly needed at this stage. In recent years, scientists based on the cholinergic hypothesis of the Alzheimer's disease1 developed systems of recording and measuring the pupil size (pupillometry) finding out that the pupil light reflex (PLR) responded in a particular way in Alzheimer's disease patients. Today imaging methods are an integral part of the diagnostic work-up of patients with suspected dementia. MRI provides data of in vivo tissue and enables evaluation of brain structures such as the hippocampus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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