Highly enantioselective direct vinylogous Michael addition of γ-butenolide to enals

Autor:	Alexandre Alexakis, Adrien Quintard, Alice Lefranc
Rok vydání:	2011
Předmět:	Aldehydes Molecular Structure Chemistry Stereochemistry Organic Chemistry Enantioselective synthesis Stereoisomerism Biochemistry Combinatorial chemistry Catalysis 4-Butyrolactone ddc:540 Michael reaction Combinatorial Chemistry Techniques Physical and Theoretical Chemistry Butenolide
Zdroj:	Organic Letters, Vol. 13, No 6 (2011) pp. 1540-1543
ISSN:	1523-7052
Popis:	An unprecedented and simple direct vinylogous addition of deconjugated butenolide to enals has been developed in excellent stereoselectivities (>95% ee), with Aminal-PYrrolidine (APY) catalyst. This methodology allows for the efficient preparation of complex γ-butenolide from readily available renewable resources. Furthermore, preliminary mechanistic investigations have allowed for the better understanding of the origin of both stereoselectivities and of the observed high reactivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dd994e423a2560f6ca3c1b2ca6813f https://pubmed.ncbi.nlm.nih.gov/21319834 Zobrazit plný text záznamu