Mechanism of transfer of bleomycin into lymphatics by bifunctional delivery system via lumen of small intestine
| Autor: | Naoko Sugihira, Shozo Muranishi, Hitoshi Sezaki, Hiroshi Yoshikawa |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Lumen (anatomy) Bleomycin Micelle Lymphatic System chemistry.chemical_compound Intestine Small Drug Discovery medicine Animals Sulfate Bifunctional Biological Transport Rats Inbred Strains General Chemistry General Medicine respiratory system Small intestine Rats respiratory tract diseases carbohydrates (lipids) Lymphatic system medicine.anatomical_structure chemistry Biochemistry Biophysics Lymph |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 31:1726-1732 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | The mechanism of lymphatic transfer of bleomycin from the lumen of the small intestine of rats following the administration of a bifunctional delivery system was investigated. This system is a combination of macromolecular bleomycin·dextran sulfate complex as a lymphotropic carrier and lipid-surfactant mixed micelles as an absorption promoter. After administration of this bifunctional delivery system into the lumen of the small intestine, 56% of the complex was left intact in the lumen after 2 h, but 85, 95 and 97% of the absorbed bleomycin were detected as the free drug in the tissue of the small intestine, the lymph and the blood, respectively. The absorption percentage of bleomycin from the lumen of the small intestine at 3 h after the administration of the bifunctional delivery system was significantly different from that of dextran sulfate, and the total lymphatic transfer of dextran sulfate was greater than that of bleomycin. These findings suggest that the extent of the selective lymphatic transfer of bleomycin was smaller than that of dextran sulfate because of the dissociation of the bleomycin·dextran sulfate complex in the lumen and the tissue of the small intestine. |
| Databáze: | OpenAIRE |
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