Relation between aerobic capacity and extent of myocardial ischemia in patients with normal cardiac function
Autor: | Shimon Spitzer, Gershon Fink, Nili Zafrir, E Klainman, Jacqueline Sulkes |
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Rok vydání: | 1999 |
Předmět: |
Male
medicine.medical_specialty Anaerobic Threshold Ischemia Myocardial Ischemia Infarction Perfusion scanning Coronary Disease Coronary artery disease Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Radionuclide Imaging Aged Vascular disease business.industry Hemodynamics medicine.disease Thallium Radioisotopes Heart failure Cardiology Exercise Test Female Cardiology and Cardiovascular Medicine business Anaerobic exercise |
Zdroj: | American heart journal. 138(6 Pt 1) |
ISSN: | 0002-8703 |
Popis: | The relation between aerobic capacity and extent of exercise-induced myocardial ischemia has not been investigated. Fifty patients with coronary artery disease (/=50% stenosis) without myocardial infarction underwent cardiopulmonary exercise testing followed by quantitative thallium perfusion imaging. Results were compared with those of age- and sex-matched healthy controls with a low likelihood of coronary artery disease. Patients with Q-wave infarction, pulmonary disease, and peripheral vascular disease were excluded. Cardiopulmonary exercise testing and thallium perfusion imaging parameters were correlated for extent of global ischemia, occurrence of increased pulmonary thallium uptake, and transient ventricular dilatation during exercise.Patients with global ischemia20% (group 1, n = 25) had normal cardiopulmonary exercise testing results, similar to the control group, except for workload and maximal predicted heart rate, which were reduced. However, patients with ischemia/=20% (group 2, n = 25) had poor cardiopulmonary exercise testing results compared with the controls. The ventilatory anaerobic threshold showed the most significant decrease of all cardiopulmonary exercise testing parameters (48% +/- 6% vs 57% +/- 6%, P.0001), and it was the only parameter to correlate with extent of ischemia (r = -0.5; P.003) as well as frequency of increased pulmonary uptake and transient ventricular dilatation (r = -0.33, P =.03).Ventilatory anaerobic threshold is significantly related to extent of myocardial ischemia and signs of heart failure during exercise. However, patients with mild to moderate exercise-induced ischemia may have normal cardiopulmonary exercise testing performance. |
Databáze: | OpenAIRE |
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