The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity
| Autor: | Piotr Myśliwiec, Mateusz Maciejczyk, Hanna Myśliwiec, Piotr Wojskowicz, Katarzyna Choromańska, Jacek Dadan, Magdalena Łuba, Anna Zalewska, Barbara Choromańska |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Biochemistry chemistry.chemical_compound Metabolic Syndrome biology Glutathione Disulfide Nitrotyrosine 05 social sciences General Medicine Middle Aged Glutathione Obesity Morbid Nitrosative Stress Myeloperoxidase Area Under Curve Hypertension Female Oxidation-Reduction Peroxynitrite Research Article Adult medicine.medical_specialty Article Subject Nitric Oxide Nitric oxide Morbid obesity 03 medical and health sciences Internal medicine Peroxynitrous Acid 0502 economics and business medicine Humans In patient Sulfhydryl Compounds Peroxidase QH573-671 business.industry Cell Biology medicine.disease Obesity 030104 developmental biology Endocrinology chemistry ROC Curve biology.protein Tyrosine 050211 marketing Metabolic syndrome Cytology business |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2020 (2020) |
| ISSN: | 1942-0900 |
| DOI: | 10.1155/2020/1057570 |
| Popis: | In this pathbreaking study, we evaluated nitrosative stress in morbidly obese patients with and without metabolic syndrome. 62 women with class 3 obesity (BMI>40 kg/m2) were divided into three subgroups: obese patients (OB), obese patients with hypertension (OB+HYP), and obese patients with metabolic syndrome (OB+MS). In comparison to the lean patients, OB had increased levels of serum myeloperoxidase (MPO), plasma nitric oxide (NO), S-nitrosothiols, and peroxynitrite (ONOO−), as well as nitrotyrosine, while oxidized glutathione (GSSG) rose only in OB+HYP group. Interestingly, ONOO− was significantly higher in OB+HYP and OB+MS as compared to OB group, while MPO only in OB+MS group. OB+MS had greater nitrotyrosine and S-nitrosothiol values than OB+HYP. Moreover, peroxynitrite could differentiate OB from OB+HYP and OB+MS (AUC 0.9292; p<0.0001; 87.5% sensitivity, 90% specificity) as well as between OB and OB+MS group (AUC 0.9125; p<0.0001; 81.25% sensitivity, 83.33%). In conclusion, we showed that MPO activity, NO formation, and nitrosative damage to proteins parallel the progression of metabolic disturbances of obesity. Evaluation of ONOO− concentrations may help predict the development of hypertension and metabolic syndrome in patients with morbid obesity; however, longer-term studies are required for larger numbers of patients. |
| Databáze: | OpenAIRE |
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