| Autor: |
Karen S.L. Lam, Vicky W K Chau, Kathryn C.B. Tan, Joanne K.Y. Lam, Carol H.Y. Fong, Yu Cho Woo, Chi Ho Lee, David T W Lui, Wing Sun Chow, Kristy Man‐yi Yeung, Alan C.H. Lee |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of the Endocrine Society |
| ISSN: |
2472-1972 |
| Popis: |
Introduction: Prediabetes has been reported to be associated with a worse trabecular bone score (TBS). Fibroblast growth factor 21 (FGF21) levels are raised in prediabetes and other insulin-resistant states, and FGF21 has been reported to be implicated in bone metabolism. We compared the bone mineral density (BMD) and TBS between prediabetes and normoglycemia, and studied the correlation of FGF21 with BMD and TBS. Method: Chinese postmenopausal women aged between 55 and 80 and without type 2 diabetes were recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study between November 2016 and October 2018. Participants were excluded if they were already on anti-osteoporosis therapy, had secondary causes of osteoporosis, had body mass index (BMI) 37 kg/m2 (when TBS measurement may not be accurate), or had an estimated glomerular filtration rate (eGFR) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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