MAPK pathway activation and the origins of pediatric low-grade astrocytomas
| Autor: | Guy F.L. Hindley, Denise Sheer, Ruth G. Tatevossian, Andrew R. J. Lawson, David W. Ellison, Tim Forshew |
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| Rok vydání: | 2009 |
| Předmět: |
Proto-Oncogene Proteins B-raf
MAPK/ERK pathway medicine.medical_specialty Adolescent MAP Kinase Signaling System Physiology Clinical Biochemistry Brain tumor Astrocytoma Biology Gene Expression Regulation Enzymologic Fusion gene Molecular genetics medicine Humans Child Gene Regulation of gene expression Brain Neoplasms Infant Newborn Infant Cell Biology medicine.disease Enzyme Activation Gene Expression Regulation Neoplastic Child Preschool Immunology Cancer research Gene Fusion Mitogen-Activated Protein Kinases |
| Zdroj: | Journal of Cellular Physiology. |
| ISSN: | 1097-4652 0021-9541 |
| DOI: | 10.1002/jcp.21978 |
| Popis: | Low-grade astrocytomas (LGAs) are the most common type of brain tumor in children. Until recently, very little was known about the underlying biology and molecular genetics of these tumors. However, within the past year a number of studies have shown that the MAPK pathway is constitutively activated in a high proportion of LGAs. Several genetic aberrations which generate this deregulation of the MAPK pathway have been identified, most notably gene fusions between KIAA1549 and BRAF. In this review we summarize these findings, discuss how these gene fusions may arise and consider possible implications for diagnosis and treatment. |
| Databáze: | OpenAIRE |
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