Twenty-six week carcinogenicity study of ampicillin in CB6F1-TgrasH2 mice
| Autor: | Kazutaka Kawashima, Chisato Yamaguchi, Tomonari Nishimura, Tamiko Adachi, Tatsuya Honda, Takaaki Yamamura, Yoshifumi Sasaki, Toshihisa Fujiwara, Toshihide Inui, Kinji Kobayashi, Yuki Kuwamura, Noriaki Tanimoto, Hirofumi Yuasa, Atsushi Koguchi |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.drug_class Ratón Carcinogenicity Tests Antibiotics Longevity Positive control Administration Oral Mice Inbred Strains Penicillins Pharmacology Toxicology Mice Ampicillin Carcinogenicity testing Medicine Animals Carcinogen Mice Knockout Dose-Response Relationship Drug business.industry Body Weight Neoplasms Experimental Dose–response relationship Genes ras Immunology Toxicity Carcinogens Female business medicine.drug |
| Zdroj: | The Journal of toxicological sciences. 27(3) |
| ISSN: | 0388-1350 |
| Popis: | As a part of the ILSI-HESI Alternative to Carcinogenicity Testing (ACT) program, we performed a 26-week carcinogenetic study of nonmutagenic drug, ampicillin (ABPC) in Tg-rasH2 mice. ABPC was given to Tg-rasH2 mice (0, 350, 1000, 3000 mg/kg, p.o.) and Non-Tg mice (0, 3000 mg/kg, p.o.) daily for 26 weeks. As a positive control, a single dose of MNU was administered once to Tg-rasH2 mice (75 mg/kg, i.p.). In this study, Tg-rasH2 mice did not demonstrate any increases in tumor development in response to ABPC. Thus, ABPC had no carcinogenicity in the 26-week carcinogenesis study in Tg-rasH2 mice or in a 2-year carcinogenesis study in B6C3F1 mice. |
| Databáze: | OpenAIRE |
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