CD36 gene polymorphism is associated with Alzheimer's disease

Autor: Vladimir J. Balcar, Alice Hálová, Vladimir Janout, Laura Ewerlingová, Jan Lochman, Jana Janoutová, Naim Akhtar Khan, Omar Šerý
Přispěvatelé: Department of biochemistry, Masaryk University, Masaryk University [Brno] (MUNI), Institute of Animal Physiology and Genetics (Brno), Institute of Animal Physiology and Genetics, Department of Epidemiology and Public Health [university of Ostrava], Lékařská fakulta / Faculty of Medicine [University of Ostrava], Ostravská univerzita / University of Ostrava-Ostravská univerzita / University of Ostrava, Equipe NuTox (LNC - U1231) (NUTOX), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Bosch Institute [Sydney], The University of Sydney, Discipline of Anatomy and Histology {University of Sydney], Masaryk University, Equipe NuTox (LNC - U1231) ( NUTOX ), Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ), The University of Sydney [Sydney]
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Apolipoprotein E
MESH : Oxidative Stress
CD36 Antigens
Male
MESH : Polymorphism
Genetic
CD36
MESH : Aged
MESH : Alzheimer Disease
MESH : Genotype
Biochemistry
Gene
MESH: Genotype
0302 clinical medicine
MESH: Cholesterol
MESH : Female
MESH : Cholesterol
Genetics
MESH: Aged
MESH: Oxidative Stress
biology
MESH: Polymorphism
Single Nucleotide
MESH : Polymorphism
Single Nucleotide
MESH: Genetic Predisposition to Disease
General Medicine
3. Good health
MESH : Antigens
CD36
Cholesterol
Interleukin 18
Female
ApoE
Genotype
MESH : Male
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
MMSE
Association
03 medical and health sciences
Alzheimer Disease
MESH: Polymorphism
Genetic
SNP
Humans
Genetic Predisposition to Disease
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Allele
Polymorphism
[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry
Molecular Biology
Genetic association
Aged
Polymorphism
Genetic
MESH: Humans
MESH: Antigens
CD36
MESH : Humans
MESH: Male
Oxidative Stress
030104 developmental biology
biology.protein
MESH : Genetic Predisposition to Disease
Gene polymorphism
MESH: Female
030217 neurology & neurosurgery
MESH: Alzheimer Disease
Zdroj: Biochimie
Biochimie, Elsevier, 2017, 135, pp.46-53. ⟨10.1016/j.biochi.2017.01.009⟩
Biochimie, Elsevier, 2017, 135, pp.46-53. 〈http://www.sciencedirect.com/science/article/pii/S0300908416303662〉. 〈10.1016/j.biochi.2017.01.009〉
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2017.01.009⟩
Popis: IF 3.112; International audience; CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.
Databáze: OpenAIRE
Externí odkaz: