Morin inhibits Listeria monocytogenes virulence in vivo and in vitro by targeting listeriolysin O and inflammation
| Autor: | Zhongmei Wen, Gen Li, Meiyang Sun, Meng Li, Guizhen Wang, Hongtao Liu, Li Li |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Bacterial Toxins lcsh:QR1-502 Virulence Morin medicine.disease_cause Listeria infection Microbiology lcsh:Microbiology Cell Line Hemolysin Proteins Mice 03 medical and health sciences chemistry.chemical_compound Immune system Listeria monocytogenes medicine Animals Humans Listeriosis Pathogen Heat-Shock Proteins 030304 developmental biology Inflammation Flavonoids 0303 health sciences biology Anti-infection 030306 microbiology Listeriolysin O Gene Expression Regulation Bacterial biology.organism_classification medicine.disease Disease Models Animal chemistry Listeria Listeriolysin O morin Protein Multimerization Research Article |
| Zdroj: | BMC Microbiology BMC Microbiology, Vol 20, Iss 1, Pp 1-9 (2020) |
| ISSN: | 1471-2180 |
| DOI: | 10.1186/s12866-020-01807-6 |
| Popis: | Background Listeria monocytogenes (L. monocytogenes) is a global opportunistic intracellular pathogen that can cause many infections, including meningitis and abortion in humans and animals; thus, L. monocytogenes poses a great threat to public safety and the development of the aquaculture industry. The isolation rate of Listeria monocytogenes in fishery products has always been high. And the pore-forming toxin listeriolysin O (LLO) is one of the most important virulence factors of L. monocytogenes. LLO can promote cytosolic bacterial proliferation and help the pathogen evade attacks from the host immune system. In addition, L. monocytogenes infection can trigger a series of severe inflammatory reactions. Results Here, we further confirmed that morin lacking anti-Listeria activity could inhibit LLO oligomerization. We also found that morin can effectively alleviate the inflammation induced by Listeria in vivo and in vitro and exerted an obvious protective effect on infected cells and mice. Conclusions Morin does not possess anti-Listeria activity, neither does it interfere with secretion of LLO. However, morin inhibits oligomerisation of LLO and morin does reduce the inflammation caused during Listeria infection. |
| Databáze: | OpenAIRE |
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