Beneficial Effect of Angiotensin-Converting Enzyme Inhibitor on Dilated Cardiomyopathy Induced by Autoimmune Mechanism Against β1-Adrenoceptor
| Autor: | Takayuki Kurihara, T Katsuda, H Wakabayashi, Shinobu Matsui, Noboru Takekoshi, Nobuo Yamaguchi, Kohei Teraoka, Michael Fu, Mituru Hayase |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cardiomyopathy
Dilated medicine.medical_specialty Necrosis Molecular Sequence Data Cardiomyopathy Angiotensin-Converting Enzyme Inhibitors Autoimmunity Enzyme-Linked Immunosorbent Assay Lisinopril Internal medicine medicine Animals Amino Acid Sequence cardiovascular diseases Pharmacology Autoimmune disease biology business.industry Myocardium Body Weight Dilated cardiomyopathy Angiotensin-converting enzyme Organ Size medicine.disease Microscopy Electron Endocrinology Enzyme inhibitor ACE inhibitor biology.protein Immunization Rabbits Receptors Adrenergic beta-1 medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 36:S43-S48 |
| ISSN: | 0160-2446 |
| Popis: | We have shown that a peptide corresponding to the sequence of the second extracellular loop of the human beta1-adrenoceptor (beta1-peptide) was able to induce an autoimmune cardiomyopathy in rabbits. In this study, we examined the effect of angiotensin-converting enzyme inhibitor (ACEI) on beta1-peptide-induced cardiomyopathy. Rabbits were divided into four groups: (1) control group (n= 6) receiving saline injection; (2) beta1-peptide group (n = 8) immunized with beta1-peptide; (3) ACEI group (n = 6), lisinopril (3 mg/day) given orally and receiving saline injection; and (4) ACEI + beta1-peptide group (n = 7), lisinopril (3 mg/day) given orally and immunized with beta1-peptide. Our results showed that, after 1 year, all rabbits in the beta1-peptide group had an increase in heart weight, wall thinning and dilatations of both ventricles as compared with rabbits in the ACEI + beta1-peptide group that had normal heart weight and shape. All rabbits in the beta1-peptide group exhibited multifocal degeneration and necrosis of myocardial cells with moderate infiltration of inflammatory cells. In the ACEI + beta1-peptide group, three rabbits showed focal degeneration and necrosis of myocardial cells accompanied by mononuclear cells. The lesions in this group were apparently less marked than those in the beta1-peptide group. In conclusion, ACEI protects the myocardium from injury induced by an autoimmune mechanism against beta1-adrenoceptor. |
| Databáze: | OpenAIRE |
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