Moderate alcohol consumption and changes in postprandial lipoproteins of premenopausal and postmenopausal women: a diet-controlled randomized intervention study
| Autor: | Gertjan Schaafsma, Henk F. J. Hendriks, Monique Bakker, Martijn S. van der Gaag, Arie van Tol, Aafje Sierksma, Tiny Geelhoed-Mieras |
|---|---|
| Přispěvatelé: | Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding, Biochemistry, Virology |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Very low-density lipoprotein Evening Alcohol Drinking Lipoproteins chemistry.chemical_compound Internal medicine medicine Humans Life Science VLAG Human Nutrition & Health Nutrition Cross-Over Studies Triglyceride Cholesterol business.industry Humane Voeding & Gezondheid General Medicine Before Dinner Middle Aged Postprandial Period Crossover study Diet Postmenopause Postprandial Endocrinology Premenopause chemistry Female lipids (amino acids peptides and proteins) business Contraceptives Oral Lipoprotein |
| Zdroj: | Journal of Womens's Health & Gender-Based Medicine, 6, 9, 607-616 Journal of Women's Health and Gender-based Medicine 9 (2000) 6 Journal of Women's Health and Gender-based Medicine, 9(6), 607-616 Journal of Womens Health & Gender-Based Medicine, 9(6), 607-615. Mary Ann Liebert Inc. |
| ISSN: | 1524-6094 |
| Popis: | Moderate alcohol consumption is associated with a reduced risk of coronary heart disease. Earlier studies in men have shown that moderate alcohol consumption affects lipoprotein metabolism and hemostasis. In this diet-controlled, randomized, crossover trial, we investigated the effect on lipoprotein metabolism of moderate consumption of red wine or red grape juice with evening dinner for 3 weeks in premenopausal women using oral contraceptives and in postmenopausal women. After 3 weeks, blood samples were collected 1 hour before dinner up to 19 hours after starting dinner at 2-hour or 4-hour intervals. Plasma triglyceride concentrations and very low density lipoprotein (VLDL) triglyceride levels peaked 3 hours after dinner with wine in both premenopausal and postmenopausal women. After wine consumption, the overall high-density lipoprotein (HDL) cholesterol level was increased in postmenopausal women (mean increase 0.17 mmol/L, or 12%, p = 0.03), and the plasma low-density lipoprotein (LDL) cholesterol level was reduced in premenopausal women (mean reduction 0.35 mmol/L, or 12%, p = 0.01) as compared with grape juice consumption. The findings suggest that postprandial lipoprotein metabolism after moderate alcohol consumption differs between oral contraceptive-using premenopausal women and postmenopausal women. The response of postmenopausal women to alcohol resembled the response found in earlier studies in men. |
| Databáze: | OpenAIRE |
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