The anti-fibrotic agent SMP-534 attenuates bleomycin-induced pulmonary fibrosis in hamsters

Autor: Eiji Sugaru, Mutsuo Taiji, Teruhisa Tokunaga, Jun Nagamine, Makoto Kitoh, Michiko Ono-Kishino, Ryu Nagata, Tsutomu Nakagawa, Tsuyoshi Tsujimura
Rok vydání: 2009
Předmět:
Zdroj: Biomedical Research. 30:177-182
ISSN: 1880-313X
0388-6107
DOI: 10.2220/biomedres.30.177
Popis: Pulmonary fibrosis is a progressive and lethal lung disease characterized by accumulation of ECM and loss of pulmonary function. However, no cure exists for this disease, and current treatments often fail to slow its progression or relieve its symptoms. We have previously reported that the anti-fibrotic agent SMP-534 has beneficial effects on renal fibrosis in animal model of nephropathy. In this study, we examined whether SMP-534 has beneficial effects on pulmonary fibrosis in bleomycin-treated hamsters. Treatment with SMP-534 [low dose (70 mg/kg) or high dose (110 mg/kg)] counteracted inhibition of body weight increase induced by bleomycin. In addition, SMP-534 significantly inhibited bleomycin-induced increase in lung hydroxyproline level, an index of collagen formation. Moreover, SMP-534 significantly ameliorated histological pulmonary fibrotic changes induced by bleomycin. The results of this study indicate that the anti-fibrotic agent SMP-534 may offer a new therapeutic option for the treatment of pulmonary fibrosis.
Databáze: OpenAIRE