The anti-fibrotic agent SMP-534 attenuates bleomycin-induced pulmonary fibrosis in hamsters
Autor: | Eiji Sugaru, Mutsuo Taiji, Teruhisa Tokunaga, Jun Nagamine, Makoto Kitoh, Michiko Ono-Kishino, Ryu Nagata, Tsutomu Nakagawa, Tsuyoshi Tsujimura |
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Rok vydání: | 2009 |
Předmět: |
Male
Pathology medicine.medical_specialty medicine.drug_class Pulmonary Fibrosis Antibiotics Pharmacology Bleomycin General Biochemistry Genetics and Molecular Biology Nephropathy Pulmonary function testing Random Allocation chemistry.chemical_compound Hydroxyproline Cricetulus Cricetinae Pulmonary fibrosis medicine Renal fibrosis Animals Humans Antibiotics Antineoplastic Lung business.industry Body Weight General Medicine medicine.disease Extracellular Matrix medicine.anatomical_structure chemistry Benzamides business |
Zdroj: | Biomedical Research. 30:177-182 |
ISSN: | 1880-313X 0388-6107 |
DOI: | 10.2220/biomedres.30.177 |
Popis: | Pulmonary fibrosis is a progressive and lethal lung disease characterized by accumulation of ECM and loss of pulmonary function. However, no cure exists for this disease, and current treatments often fail to slow its progression or relieve its symptoms. We have previously reported that the anti-fibrotic agent SMP-534 has beneficial effects on renal fibrosis in animal model of nephropathy. In this study, we examined whether SMP-534 has beneficial effects on pulmonary fibrosis in bleomycin-treated hamsters. Treatment with SMP-534 [low dose (70 mg/kg) or high dose (110 mg/kg)] counteracted inhibition of body weight increase induced by bleomycin. In addition, SMP-534 significantly inhibited bleomycin-induced increase in lung hydroxyproline level, an index of collagen formation. Moreover, SMP-534 significantly ameliorated histological pulmonary fibrotic changes induced by bleomycin. The results of this study indicate that the anti-fibrotic agent SMP-534 may offer a new therapeutic option for the treatment of pulmonary fibrosis. |
Databáze: | OpenAIRE |
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