Long-Lasting Muscle Relaxant Activity of Eperisone Hydrochloride after Percutaneous Administration in Rats
| Autor: | Shigeru Tanaka, Manabu Matsunaga, Yuji Atsuta, Yukio Nishizawa, Hironori Etoh, Yoshiharu Yamanishi, Yuji Uemura, Kazumi Kanai, Yuri Yonemoto |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Tolperisone medicine.drug_class Muscle Relaxation Hindlimb Pharmacology Administration Cutaneous Image Processing Computer-Assisted Animals Medicine Potency Rats Wistar Muscle Skeletal Chromatography High Pressure Liquid Eperisone Decerebrate State Analysis of Variance Propiophenones Dose-Response Relationship Drug Electromyography Muscle Relaxants Central business.industry Muscle relaxant Reference Standards Muscle Rigidity Rats Disease Models Animal Dose–response relationship Muscle relaxation Anesthesia Injections Intravenous business medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 73:215-220 |
| ISSN: | 0021-5198 |
| Popis: | Potency and duration of muscle relaxant activity of eperisone hydrochloride were examined after percutaneous administration in the intercollicular decerebrated rat rigidity model and compared to those of eperisone after intravenous injection. A continuous movement was loaded on the hindlimb of the rat model to maintain stable rigidity. The tonus of the hindlimb was recorded by EMG from the triceps surae and was quantified by using the public domain NIH Image program. Eperisone ointment administered percutaneously showed significant muscle relaxant activity at 8.4 cm2 (4.2 mg of eperisone)/rat. The effect was dose-dependent and lasted over 60 min. Intravenously injected eperisone showed significant activity at 1.25 mg/kg, but the decrease of tone was lost within 30 min after injection. Plasma eperisone levels were monitored in the same model, and they were well correlated to the dosage. These results suggest that percutaneously administered eperisone is absorbed efficiently and shows potent and long-lasting muscle relaxant activity. |
| Databáze: | OpenAIRE |
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