Visceral white fat remodelling contributes to intermittent hypoxia-induced atherogenesis

Autor: Maurice Dematteis, Patrick Levy, Claire Arnaud, Amandine Thomas, Louis Casteilla, Laureline Poulain, Jennifer Rieusset
Přispěvatelé: Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA)
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Necrosis
Adipose Tissue
White
[SDV]Life Sciences [q-bio]
Adipose tissue
Inflammation
White adipose tissue
Intra-Abdominal Fat
Ion Channels
Mitochondrial Proteins
Mice
White/*pathology"*"Animals"*"*Anoxia"*"Aorta/pathology"*"Atherosclerosis/*pathology"*"Chemokine CCL2/metabolism"*"Glucose Tolerance Test"*"Inflammation"*"Insulin Resistance"*"Intra-Abdominal Fat/*pathology"*"Ion Channels/metabolism"*"Male"*"Mice"*"Mice
Insulin resistance
Internal medicine
medicine
Animals
Hypoxia
Aorta
Chemokine CCL2
Uncoupling Protein 1
business.industry
Intermittent hypoxia
Hypoxia (medical)
Glucose Tolerance Test
medicine.disease
Atherosclerosis
Thermogenin
3. Good health
Mice
Inbred C57BL
Endocrinology
Adipose Tissue
medicine.symptom
Insulin Resistance
business
Inbred C57BL"*"Mitochondrial Proteins/metabolism
Zdroj: European Respiratory Journal
European Respiratory Journal, European Respiratory Society, 2014, 43 (2), pp.513-522. ⟨10.1183/09031936.00019913⟩
ISSN: 0903-1936
1399-3003
DOI: 10.1183/09031936.00019913⟩
Popis: International audience; Obstructive sleep apnoea is a highly prevalent disease characterised by repetitive upper airway collapse during sleep leading to intermittent hypoxia. Cardiometabolic complications of sleep apnoea have been mostly attributed to intermittent hypoxia. These consequences could be mediated through intermittent hypoxia-related alterations of the visceral white fat, as it is recognised for playing an important role in inflammation, atherogenesis and insulin resistance. Epididymal adipose tissue alterations were investigated in 20-week-old nonobese male apolipoprotein E-deficient mice exposed to intermittent hypoxia (inspiratory oxygen fraction 5-21%, 60-s cycle, 8 h . day(-1)) or air for 6 weeks. These adipose tissue alterations, as well as metabolic alterations and aortic atherosclerosis, were then assessed in lipectomised or sham-operated mice exposed to intermittent hypoxia or air for 6 weeks. Intermittent hypoxia induced morphological (shrunken adipocytes), functional (increased uncoupling protein-1 expression) and inflammatory (increased macrophage recruitment and secretion of interleukin-6 and tumour necrosis factor-alpha) remodelling of epididymal adipose tissue. Hypoxic mice presented more severe dyslipidaemia and atherosclerosis lesions and developed insulin resistance. Epididymal lipectomy attenuated both intermittent hypoxia-induced dyslipidaemia and atherogenesis, but did not improve insulin sensitivity. Our results confirmed that the dyslipidaemic and proatherogenic effects of intermittent hypoxia are partly mediated through morphological, functional and inflammatory remodelling of visceral white fat, regardless of obesity.
Databáze: OpenAIRE
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