Pharmacokinetics and Tissue Distribution of Recombinant Human Alpha A, D, A/D(Bgl), and I Interferons and Mouse Alpha-Interferon in Mice
| Autor: | Oksana Bohoslawec, Robert J. Wills, Patrick W. Trown |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Immunology Biological Transport Active Alpha interferon Biology Kidney law.invention Mice Species Specificity Pharmacokinetics law Interferon Virology Internal medicine medicine Animals Humans Tissue Distribution Interferon alfa Volume of distribution Kidney metabolism Kinetics medicine.anatomical_structure Endocrinology Interferon Type I Recombinant DNA medicine.drug |
| Zdroj: | Journal of Interferon Research. 6:207-213 |
| ISSN: | 0197-8357 |
| DOI: | 10.1089/jir.1986.6.207 |
| Popis: | The pharmacokinetics and tissue distribution in mice of several recombinant human alpha-interferons [rHuIFN-alpha A, D, I, and A/D(Bgl)] as well as natural mouse alpha-interferon (MuIFN-alpha) were assessed following single intravenous injections. The serum profiles of rHuIFN-alpha A, rHuIFN-alpha D, rHuIFN-alpha A/D(Bgl), and MuIFN-alpha were similar, whereas those following rHuIFN-alpha I showed a much longer terminal elimination phase. Differences in elimination half-life, volume of distribution, and total body clearance between these IFNs were observed. There was appreciable uptake of IFN in the kidney: the amount of each interferon per gram of tissue in the kidney ranges from 1 to 9 times the amount found in the serum. The greatest uptake appeared with rHuIFN-alpha D, followed by rHuIFN-alpha A, rHuIFN-alpha A/D(Bgl), and MuIFN-alpha. The only exception was rHuIFN-alpha I which showed no uptake into the kidney. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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