Disease Remission in Children and Adolescents with Intermediate Uveitis: A Survival Analysis
| Autor: | Benjamín Fernández-Gutiérrez, Lydia Abasolo, Lara Borrego-Sanz, David Díaz-Valle, Luis Rodriguez-Rodriguez, Julian Garcia-Feijoo, C. López-Abad, Esperanza Pato |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Visual acuity Adolescent Remission Spontaneous Visual Acuity Spontaneous remission 03 medical and health sciences 0302 clinical medicine Recurrence Risk Factors medicine Humans Child Survival analysis Retrospective Studies 030203 arthritis & rheumatology business.industry Retrospective cohort study General Medicine medicine.disease Survival Analysis Sensory Systems Confidence interval Ophthalmology Spain Chronic Disease Disease remission 030221 ophthalmology & optometry Intermediate uveitis Female Morbidity medicine.symptom business Uveitis Intermediate Uveitis Follow-Up Studies |
| Zdroj: | Ophthalmologica. 239:151-158 |
| ISSN: | 1423-0267 0030-3755 |
| DOI: | 10.1159/000485262 |
| Popis: | Purpose: To report the incidence rate (IR) of remission in pediatric noninfectious intermediate uveitis (IU). Methods: Longitudinal retrospective cohort study, including 19 patients (32 eyes) between 1985 and 2014, followed-up until loss or January 2016. Remission was defined following the Standardization of Uveitis Nomenclature workshop criteria, prolonged remission as a remission spanning 12 months and until the end of follow-up, and relapse as recurrence of inflammatory activity in an eye in remission. Results: Median follow-up time was 6.3 years. IRs (95% confidence interval) for remission, relapse, and prolonged remission were 18.6 (13.1–26.5), 32.3 (20.6–50.7), and 6.7 (3.8–11.9) episodes per 100 eye-years, respectively. 48% of eyes relapsed in the first year following remission. 25 and 50% of eyes achieved prolonged remission after 5 and 10 years of follow-up, respectively. Conclusions: Inflammatory relapses may be frequent in noninfectious IU affecting children and adolescents, appearing early after remission. Also, prolonged remission seems infrequent, being achieved late during follow-up. |
| Databáze: | OpenAIRE |
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