Influence of hyaluronic acid on bacterial and fungal species, including clinically relevant opportunistic pathogens
| Autor: | Maria Cristina Baschieri, Elisabetta Blasi, Beniamino Palmieri, Claudio Cermelli, Elena Righi, M Caratozzolo, Andrea Ardizzoni, Rachele Giovanna Neglia |
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| Rok vydání: | 2011 |
| Předmět: |
Time Factors
Biomedical Engineering Biophysics Biocompatible Materials Bioengineering medicine.disease_cause Microbiology Biomaterials chemistry.chemical_compound Drug Resistance Fungal Drug Resistance Bacterial medicine Hyaluronic Acid Escherichia coli Hyaluronic acid Bacterial growth inhibition Fungal growth inhibition Opportunistic pathogens Bacteria Viscosupplements biology Candida glabrata Pseudomonas aeruginosa Fungi biology.organism_classification Antimicrobial Streptococcus mutans Corpus albicans Anti-Bacterial Agents chemistry Brain heart infusion |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 22:2329-2338 |
| ISSN: | 1573-4838 0957-4530 |
| DOI: | 10.1007/s10856-011-4408-2 |
| Popis: | Hyaluronic acid (HA) has several clinical applications (aesthetic surgery, dermatology, orthopaedics and ophtalmology). Following recent evidence, suggesting antimicrobial and antiviral properties for HA, we investigated its effects on 15 ATCC strains, representative of clinically relevant bacterial and fungal species. The in vitro system employed allowed to assess optical density of broth cultures as a measure of microbial load in a time-dependent manner. The results showed that different microbial species and, sometimes, different strains belonging to the same species, are differently affected by HA. In particular, staphylococci, enterococci, Streptococcus mutans, two Escherichia coli strains, Pseudomonas aeruginosa, Candida glabrata and C. parapsilosis displayed a HA dose-dependent growth inhibition; no HA effects were detected in E. coli ATCC 13768 and C. albicans; S. sanguinis was favoured by the highest HA dose. Therefore, the influence of HA on bacteria and fungi warrants further studies aimed at better establishing its relevance in clinical applications. |
| Databáze: | OpenAIRE |
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