Bullous systemic lupus erythematosus with antiphospholipid syndrome
| Autor: | Adam Klimowicz, Anna Kacalak-Rzepka, E Zaluga, R Maleszka, A Królicki |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Anti-nuclear antibody Dermatology Dapsone immune system diseases Antiphospholipid syndrome medicine Humans Lupus Erythematosus Systemic skin and connective tissue diseases Acenocoumarol Lupus erythematosus Skin Diseases Vesiculobullous biology business.industry Antiphospholipid Syndrome medicine.disease Infectious Diseases Prednisolone biology.protein Antibody business medicine.drug Anti-SSA/Ro autoantibodies |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology. 18:490-494 |
| ISSN: | 1468-3083 0926-9959 |
| Popis: | We report the case of a 44-year-old male with a 10-year history of manifestations of the rare form of bullous systemic lupus erythematosus (SLE) with coexisting antiphospholipid syndrome (APS) that remained undiagnosed until thrombotic-embolic episodes appeared and high titres of anticardiolipin (ACL) antibodies were detected. The patient fulfilled the criteria for SLE and the atypical cutaneous manifestations together with histopathological changes and a favourable response to sulphones were the grounds for the diagnosis of the bullous variety of SLE. Treatment with prednisolone, acenocoumarol and dapsone resulted in marked clinical improvement, reduction in antinuclear antibodies (ANAs) and normalization of ACL antibody titres. |
| Databáze: | OpenAIRE |
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