Time-restricted feeding prevents high-fat and high-cholesterol diet-induced obesity but fails to ameliorate atherosclerosis in apolipoprotein E-knockout mice
| Autor: | Teruo Inoue, Teruo Jojima, Shigeru Toyoda, Ken-ichi Inoue, Shichiro Abe, Masashi Sakuma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Apolipoprotein E obesity time-restricted feeding medicine.medical_specialty Original Western-style diet Physical exercise Overweight Diet High-Fat apolipoprotein E-knockout mice General Biochemistry Genetics and Molecular Biology Cholesterol Dietary Mice chemistry.chemical_compound Apolipoproteins E Internal medicine Brown adipose tissue Intermittent fasting Animals Medicine Mice Knockout General Veterinary business.industry Cholesterol Area under the curve Fasting General Medicine Atherosclerosis medicine.disease Obesity Mice Inbred C57BL medicine.anatomical_structure Endocrinology chemistry Animal Science and Zoology medicine.symptom business |
| Zdroj: | Experimental Animals |
| ISSN: | 1881-7122 1341-1357 |
| DOI: | 10.1538/expanim.20-0112 |
| Popis: | One of the leading risk factors for atherosclerosis is obesity, which is commonly caused by a nutrient-rich Western-style diet, sedentary behaviors, and shift work. Time-restricted (TR) feeding and intermittent fasting are both known to prevent overweight and adiposity, improve glucose tolerance, and decrease plasma cholesterol in high-fat diet-induced obese mice. Here we examined the overall effects of TR feeding of a Western diet (fat, 40.5 Kcal%; cholesterol, 0.21 g%) using 8-week-old Apoe−/− mice. Mice were assigned into three groups: (1) an ad libitum (AL) group fed an AL Western diet, (2) a TR group with restricted access to a Western diet (15 h/day, 12:00 to 3:00 Zeitgeber time [ZT]); and (3) an Ex/TR group fed a TR Western diet and subjected to physical exercise at 12:00 ZT. Mice in the AL group gained body weight rapidly during the 14-week observation period. With TR feeding, excessive weight gain, liver adiposity, visceral fat, and brown adipose tissue volume were effectively suppressed. Although TR feeding failed to decrease Oil Red O-stained aortic plaques in Apoe−/− mice, physical exercise significantly decreased them. Neither TR feeding with exercise nor that without exercise decreased the mean area under the curve of the plasma cholesterol level or the fasting plasma glucose. Collectively, TR feeding of a Western diet prevented the development of obesity but failed to ameliorate atherosclerosis in Apoe−/− mice. |
| Databáze: | OpenAIRE |
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