Does low-dose gapapentin reduce opioid use postoperatively?: A randomized controlled trial in women undergoing reconstructive pelvic surgery
| Autor: | Ashraf Dawood, Kristin Wadsworth, May Alarab, Naveed Siddiqui, Nucelio Lemos, Adrienne L. K. Li, Danny Lovatsis, Colleen D. McDermott |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Gabapentin Visual analogue scale Nausea Urology Sedation 030232 urology & nephrology Placebo Pelvic Organ Prolapse law.invention 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Hysterectomy Vaginal Humans Medicine Postoperative Period Pain Measurement Analgesics Pain Postoperative 030219 obstetrics & reproductive medicine Morphine business.industry Obstetrics and Gynecology Middle Aged Plastic Surgery Procedures Combined Modality Therapy Analgesics Opioid Treatment Outcome Opioid Concomitant Anesthesia Female medicine.symptom business medicine.drug |
| Zdroj: | International Urogynecology Journal. 30:211-217 |
| ISSN: | 1433-3023 0937-3462 |
| DOI: | 10.1007/s00192-018-3617-3 |
| Popis: | Pre-emptive gabapentin has been shown to decrease postoperative pain in abdominal and vaginal hysterectomy. However, the effect of pre-emptive low-dose gabapentin has not been studied in vaginal hysterectomy combined with concomitant pelvic reconstruction. A randomized double-blind placebo-controlled trial assessed all women seen for symptomatic prolapse requiring vaginal hysterectomy with concomitant pelvic reconstruction with or without midurethral sling. Gabapentin dosing was 600 mg ( 65 years). The primary outcome was reduction in opioid consumption in the first 24 h after surgery. Secondary outcomes included sedation and prolongation of recovery room stay. Sample-size calculations indicated a need for 22 participants/group. Student’s t test was used to compare differences in oral administration of morphine equivalents in the first 24 h postoperatively, time from end of surgery to leaving the recovery room, and length of recovery room stay. Mann–Whitney U test was used to compare visual analog scale (VAS) scores for anxiety, drowsiness/sedation, pain, and nausea. Twenty-one patients received gabapentin and 26 a placebo capsule. Groups were similar with respect to age, menopause status, parity, American Society of Anesthesiologist (ASA) class, and concomitant procedures. There were also no significant differences between groups in opioid requirements within the first 24 h after surgery, time from end of surgery to leaving the recovery room, length of time in recovery room, or VAS scores. Pre-emptive gabapentin at our institutional low doses did not significantly affect postoperative pain and opioid requirements in women undergoing vaginal hysterectomy with concomitant reconstruction. www.clinicaltrials.gov , #NCT02999724. |
| Databáze: | OpenAIRE |
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