Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins
| Autor: | Juko Ando, Hanna-Reetta Lajunen, Matt McGue, Michelle Luciano, Dorret I. Boomsma, Karri Silventoinen, Meike Bartels, K Nonaka, Y. M. Hur, Mingguang He, Jaakko Kaprio, William G. Iacono, C C H Lin, Karen S. Mitchell, Richard J. Rose, C.E.M. van Beijsterveldt, Peter M. Visscher, Belinda K. Cornes, Stacey S. Cherny, Nicholas G. Martin, Syuichi Ooki |
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| Přispěvatelé: | Biological Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Netherlands Twin Register (NTR)
Male Adolescent Endocrinology Diabetes and Metabolism Population Twins Medicine (miscellaneous) 030209 endocrinology & metabolism Biology Article White People Body Mass Index 03 medical and health sciences BMI 0302 clinical medicine Asian People medicine Twins Dizygotic Humans East Asia 10. No inequality education 030304 developmental biology Genetic association 2. Zero hunger 0303 health sciences education.field_of_study Sex Characteristics Nutrition and Dietetics Population group Height Body Weight Twins Monozygotic medicine.disease Weight Obesity Twin study Body Height Genes Trait Female Body mass index Demography Sex characteristics |
| Zdroj: | International Journal of Obesity, 32(10), 1455-1467. Nature Publishing Group Hur, Y M, Kaprio, J, Iacono, W G, Boomsma, D I, McGue, M, Silventoinen, K, Martin, N G, Luciano, M, Visscher, P M, Rose, R J, He, M, Ando, J, Ooki, S, Nonaka, K, Lin, C C H, Lajunen, H R, Cornes, B K, Bartels, M, van Beijsterveldt, C E M, Cherny, S S & Mitchell, K 2008, ' Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins. ', International Journal of Obesity, vol. 32, no. 10, pp. 1455-1467 . https://doi.org/10.1038/ijo.2008.144 |
| ISSN: | 0307-0565 |
| Popis: | Objective: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were two-fold: First, we aimed to compare the total phenotypic, genetic and environmental variances of height, weight and BMI between Caucasians and East Asians using twins. Secondly, we intended to estimate the extent to which genetic and environmental factors contribute to differences in variability of height, weight and BMI between Caucasians and East Asians. Design: Height and weight data from 3735 Caucasian and 1584 East Asian twin pairs (age: 13-15 years) from Australia, China, Finland, Japan, the Netherlands, South Korea, Taiwan and the United States were used for analyses. Maximum likelihood twin correlations and variance components model-fitting analyses were conducted to fulfill the goals of the present study. Results: The absolute genetic variances for height, weight and BMI were consistently greater in Caucasians than in East Asians with corresponding differences in total variances for all three body measures. In all 80 to 100% of the differences in total variances of height, weight and BMI between the two population groups were associated with genetic differences. Conclusion: Height, weight and BMI were more variable in Caucasian than in East Asian adolescents. Genetic variances for these three body measures were also larger in Caucasians than in East Asians. Variance components model-fitting analyses indicated that genetic factors contributed to the difference in variability of height, weight and BMI between the two population groups. Association studies for these body measures should take account of our findings of differences in genetic variances between the two population groups. © 2008 Macmillan Publishers Limited All rights reserved. link_to_subscribed_fulltext |
| Databáze: | OpenAIRE |
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