[Arterial hypertension and prediabetes]
| Autor: | Patricia Boned Ombuena, José Antonio Costa Muñoz, Jose Maria Pascual Izuel, Enrique Rodilla Sala |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty 030204 cardiovascular system & hematology Prediabetic State 03 medical and health sciences 0302 clinical medicine Interquartile range Risk Factors Diabetes mellitus Internal medicine medicine Humans 030212 general & internal medicine Prediabetes Prospective Studies Family history Aged Proportional Hazards Models Aged 80 and over business.industry Proportional hazards model Middle Aged medicine.disease Combined Modality Therapy Confidence interval Primary Prevention Endocrinology Blood pressure Diabetes Mellitus Type 2 Hypertension Female Metabolic syndrome business Follow-Up Studies |
| Zdroj: | Medicina clinica. 147(9) |
| ISSN: | 1578-8989 |
| Popis: | Background and objectives The aim of this study was to assess the factors related to new diabetes in hypertensive. Patients and methods This prospective follow-up study involved 2588 non-diabetic, hypertensive patients. The total follow-up was 15,053 patient-years with a median of 3.4 years (interquartile interval 1.4–6.8). Results During the follow-up, 333 (13%) patients had new diabetes, with a conversion rate of 2.21 (95% confidence interval [CI], 1.98–2.46) 100/patients/year. In a Cox proportional hazard model including baseline characteristics and modifications during the follow-up the three components of metabolic syndrome (excluding blood pressure and glucose values) HR 1.69 (95% CI, 1.36–2.09), family history of diabetes HR 1.49 (95% CI, 1.20–1.85) and baseline blood glucose ≥110 mg/dl HR 7.84 (95% CI, 5.99–10.29) were the most important factors related to new diabetes. Weight variation during the follow-up, and statins, beta-blockers or diuretic treatment did not increase the risk of new diabetes, blood pressure control at the end of study reduce the risk HR 0.74 (95% CI, 0.61–0.91). Conclusions In hypertensive non-diabetic patients in primary prevention the factors related to new diabetes can easily identified at the beginning of follow-up. Being obese, with family history of diabetes, and glucose values ≥110 mg/dl dramatically increase the risk of developing new diabetes. |
| Databáze: | OpenAIRE |
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