Glutamate and theta-rhythm stimulation selectively enhance NMDA component of EPSC in CA1 neurons of young rats
| Autor: | Y u Kovalchuk, Oleg Krishtal, Olga Garaschuk |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Aging
N-Methylaspartate Glutamic Acid Stimulation Biology Neurotransmission In Vitro Techniques Arginine Nitroarginine Synaptic Transmission Hemoglobins Norepinephrine Glutamates Animals Patch clamp Rats Wistar Theta Rhythm Evoked Potentials Neurons Neuronal Plasticity musculoskeletal neural and ocular physiology General Neuroscience Glutamate receptor Rats Electrophysiology nervous system Synaptic plasticity Synapses Excitatory postsynaptic potential NMDA receptor Neuroscience |
| Zdroj: | Neuroscience letters. 151(1) |
| ISSN: | 0304-3940 |
| Popis: | Using in situ whole-cell patch clamp of hippocampal CA1 pyramidal neurons we demonstrate that glutamate initiates processes resulting in an increase in the amplitude of the excitatory post-synaptic current (EPSC). In adult animals both, NMDA and non-NMDA components of the EPSC increase in parallel. In young animals only the NMDA component is increased. A similar enhancement of the EPSC can be achieved by the stimulation of excitatory synaptic inputs to CA1 neurons with the frequency of the theta-rhythm. EPSCs remain enhanced for more than 60 min. The selective enhancement of the NMDA component in young animals is inhibited by preincubation of slices with the NO-synthase blocker, N omega-nitro-L-arginine (NA) or by the NO-scavenger, hemoglobin. |
| Databáze: | OpenAIRE |
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