Temperate and chronic virus competition leads to low lysogen frequency
| Autor: | Sara M. Clifton, Rachel J. Whitaker, Zoi Rapti |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Statistics and Probability viruses media_common.quotation_subject Cell Genome Viral General Biochemistry Genetics and Molecular Biology Competition (biology) Virus Bacteriophage 03 medical and health sciences 0302 clinical medicine Lysogen Lysogenic cycle medicine Humans Bacteriophages Quantitative Biology - Populations and Evolution Lysogeny media_common Bacteria General Immunology and Microbiology biology Applied Mathematics Populations and Evolution (q-bio.PE) General Medicine biology.organism_classification Virology 030104 developmental biology medicine.anatomical_structure Lytic cycle FOS: Biological sciences Modeling and Simulation General Agricultural and Biological Sciences 030217 neurology & neurosurgery |
| Zdroj: | Journal of Theoretical Biology. 523:110710 |
| ISSN: | 0022-5193 |
| DOI: | 10.1016/j.jtbi.2021.110710 |
| Popis: | The canonical bacteriophage is obligately lytic: the virus infects a bacterium and hijacks cell functions to produce large numbers of new viruses which burst from the cell. These viruses are well-studied, but there exist a wide range of coexisting virus lifestyles that are less understood. Temperate viruses exhibit both a lytic cycle and a latent (lysogenic) cycle, in which viral genomes are integrated into the bacterial host. Meanwhile, chronic (persistent) viruses use cell functions to produce more viruses without killing the cell; chronic viruses may also exhibit a latent stage in addition to the productive stage. Here, we study the ecology of these competing viral strategies. We demonstrate the conditions under which each strategy is dominant, which aids in control of human bacterial infections using viruses. We find that low lysogen frequencies provide competitive advantages for both virus types; however, chronic viruses maximize steady state density by eliminating lysogeny entirely, while temperate viruses exhibit a non-zero 'sweet spot' lysogen frequency. Viral steady state density maximization leads to coexistence of temperate and chronic viruses, explaining the presence of multiple viral strategies in natural environments. |
| Databáze: | OpenAIRE |
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